| First Author | Panten J | Year | 2024 |
| Journal | Nat Commun | Volume | 15 |
| Issue | 1 | Pages | 8814 |
| PubMed ID | 39394207 | Mgi Jnum | J:357755 |
| Mgi Id | MGI:7749578 | Doi | 10.1038/s41467-024-52640-8 |
| Citation | Panten J, et al. (2024) Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage. Nat Commun 15(1):8814 |
| abstractText | The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the Y(Sry-) chromosome and thus increased the expression of X-linked genes including the single-stranded RNA sensor and autoimmune disease mediator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on C57BL/6J FCG mice. |
