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Publication : Enteric glial hub cells coordinate intestinal motility.

First Author  Scavuzzo MA Year  2023
Journal  bioRxiv PubMed ID  37333182
Mgi Jnum  J:356201 Mgi Id  MGI:7762293
Doi  10.1101/2023.06.07.544052 Citation  Scavuzzo MA, et al. (2023) Enteric glial hub cells coordinate intestinal motility. bioRxiv
abstractText  Enteric glia are the predominant cell type in the enteric nervous system yet their identities and roles in gastrointestinal function are not well classified. Using our optimized single nucleus RNA-sequencing method, we identified distinct molecular classes of enteric glia and defined their morphological and spatial diversity. Our findings revealed a functionally specialized biosensor subtype of enteric glia that we call "hub cells." Deletion of the mechanosensory ion channel PIEZO2 from adult enteric glial hub cells, but not other subtypes of enteric glia, led to defects in intestinal motility and gastric emptying in mice. These results provide insight into the multifaceted functions of different enteric glial cell subtypes in gut health and emphasize that therapies targeting enteric glia could advance the treatment of gastrointestinal diseases.
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