| First Author | Yamamoto Y | Year | 2010 |
| Journal | J Neuroimmunol | Volume | 229 |
| Issue | 1-2 | Pages | 129-39 |
| PubMed ID | 20805006 | Mgi Jnum | J:356326 |
| Mgi Id | MGI:7762418 | Doi | 10.1016/j.jneuroim.2010.07.024 |
| Citation | Yamamoto Y, et al. (2010) Interleukin-18 deficiency reduces neuropeptide gene expressions in the mouse amygdala related with behavioral change. J Neuroimmunol 229(1-2):129-39 |
| abstractText | In this study, we examined the effects of IL-18 deficiency on behaviors and gene expression profiles in 6 brain regions. IL-18(-/-) mice reduced depressive-like behavior and changed gene expressions predominantly in the amygdala compared with wild-type mice. Pathway analysis of the differentially expressed genes ranked behavior as the top-scored biological function. Of note, the absence of IL-18 decreased Avp, Hcrt, Oxt, and Pmch mRNA levels and the number of arginine vasopressin- and oxytocin-positive cells in the amygdala, but not in the hypothalamus. Our results suggest that IL-18-dependent vasopressinergic and oxytocinergic circuitry in the amygdala may regulate depressive-like behaviors in mice. |
