| Primary Identifier | IPR047538 | Type | Domain |
| Short Name | KH-I_ASCC1 |
| description | This entry represents the type I KH RNA-binding domain of ASCC1 from animals.ASCC1, also called ASC-1 complex subunit p50, or Trip4 complex subunit p50, plays a role in DNA damage repair as component of the ASCC complex which consists of ASCC1, ASCC2 and ASCC3 subunits (p50, p100 and p200, respectively) [, ]. It is part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation []. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin []. ASCC1 may also play a role in the development of neuromuscular junction []. This protein has an RNA-binding KH domain fused to a 2H RNA-phosphoesterase [, ]and modulates the ASCC3 helicase recruitment to the ASCC complex during alkylation damage. |
