| Primary Identifier | IPR053089 | Type | Family |
| Short Name | ARHGEF18 |
| description | Rho guanine nucleotide exchange factor 18 (ARHGEF18, also known as p114RhoGEF) acts as a guanine nucleotide exchange factor (GEF) for RhoA and RAC1 GTPases, but not for CDC42. Its activation induces the formation of actin stress fibres and the production of reactive oxygen species (ROS) [, ]. It is activated by the G protein ��-�� subunits of heterotrimeric G proteins []. ARHGEF18 is required for the regulation of the circumferential actomyosin belt in epithelial cells, interacting with proteins such as EPB41L4B and PATJ []. It also interacts with SEPT9, which may inhibit its GEF activity []. In humans, defects in ARHGEF18 are the cause of retinitis pigmentosa 78 (RP78), an autosomal recessive retinal dystrophy []. The protein typically contains a Dbl homology (DH) domain and a Pleckstrin homology (PH) domain. |
