| Primary Identifier | IPR038892 | Type | Family |
| Short Name | SMCHD1 |
| description | This entry represents structural maintenance of chromosomes flexible hinge domain-containing (SMC-FH) animal proteins, including human Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1)SMC-FH proteins are atypical SMC proteins, characterised by their unique homodimeric arrangement and ATPase activity. SMC-FH plays a crucial role in epigenetic silencing by regulating chromatin architecture and promoting heterochromatin formation on both autosomes and the X chromosome. It is essential for X chromosome inactivation in females, facilitating the spreading of heterochromatin and creating a compartment-less nuclear architecture. Additionally, it is involved in silencing specific autosomal loci and contributes to DNA repair by promotingnon-homologous end joining and inhibiting homologous recombination [, , , ]. |
