| Primary Identifier | IPR049579 | Type | Family |
| Short Name | GPR26/78-like |
| description | This entry represents human G-protein coupled receptors 26 and 78 (GPR26778) and similar proteins from vertebrates. These proteins are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown []. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviours, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia [, , , , ].All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) ��-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signalling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes [, , , , , , ]. |
