| Primary Identifier | IPR065527 | Type | Family |
| Short Name | 7tmA_5-HT4R |
| description | The 5-hydroxytryptamine receptor 4 (5-HT4R) is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptor binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS) []. 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A [, , , , ]. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising seven-transmembrane (TM) ��-helices interconnected by three extracellular and three intracellular loops []. A general feature of GPCR signalling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits []. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes []. |
