| Primary Identifier | IPR047908 | Type | Domain |
| Short Name | TSSK4_cat |
| description | Testis-specific serine/threonine-protein kinases (TSSKs) are almost exclusively expressed post meiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis [, , ]. There are five mammalian TSSK proteins which show differences in their localisation and timing of expression [, , ]. This entry represents the catalytic domain of TSSK4, also called TSSK5, which is expressed in testis from haploid round spermatids to mature spermatozoa. It mediates its autophosphorylation at Thr-197 in the T-loop region which is essential to its kinase activity [, ]. It phosphorylates Cre-Responsive Element Binding protein (CREB), facilitating the binding of CREB to the specific cis cAMP responsive element (CRE), which is important in activating genes related to germ cell differentiation []. Mutations in the human TSSK4 gene is associated with infertile Chinese men with impaired spermatogenesis []. |
