| Primary Identifier | IPR048829 | Type | Repeat |
| Short Name | PCF11_RFEG_rpt |
| description | This entry represents a repeat region found in Pre-mRNA cleavage complex 2 protein Pcf11 from human () and similar proteins from vertebrates. This repeat is about thirteen amino acids with a high content of proline and glycine residues, however, it varies in length among the sequences included in this entry. These repeats contain the highly conserved RFE/DG motif, conserved in PCF11 orthologues in vertebrates but not in Drosophila, C. elegans, or yeast []. It has been described that human PCF11 has 30 repeats of the RFE/DG motif (referred as FEGP in []) which are necessary for pre-mRNA cleavage complex II (CFII) activity []. PCF11 is a subunit and an essential component of CFII (the orthologue of cleavage and polyadenylation factor IA (CFIA) from yeast) which is involved in pre-mRNA 3' end processing and in transcription termination []. PCF11 is thought to be one of the scaffold proteins of the processing complex. PCF11-mediated termination is essential for vertebrate development []. |
