| Primary Identifier | IPR048830 | Type | Domain |
| Short Name | PCF11_helical |
| description | This entry represents the ��-helical domain found adjacent the CID domain in Pre-mRNA cleavage complex 2 protein Pcf11 from human and similar animal proteins whose function is unknown []. Pcf11 is a subunit and an essential component of CFII (the orthologue of cleavage and polyadenylation factor IA (CFIA) from yeast) which is involved in pre-mRNA 3' end processing and in transcription termination [, , ]. PCF11 is thought to be one of the scaffold proteins of the processing complex. PCF11-mediated termination is essential for vertebrate development []. |
