| Primary Identifier | IPR019316 | Type | Domain |
| Short Name | G8_domain |
| description | This entry represents a domain found in disease proteins PKHD1 and CEMIP2 (also known as KIAA1199) and is named G8 after its 8 conserved glycines. It is predicted to contain 10 ��-strands and an ��-helix [, ]. CEMIP2 is an inactive cell surface hyaluronidase that, unlike its mouse orthologue, has no catalytic hyaluronic acid-degrading activity, but acts as a regulator of hyaluronan (HA) metabolism through regulation of expression of CEMIP and HAS2, two enzymes involved in HA depolymerization and HA synthesis, respectively [, ]. |
