| Primary Identifier | IPR054596 | Type | Domain |
| Short Name | PARP14_WWE |
| description | This entry represents the WWE domain of protein mono-ADP-ribosyltransferase PARP14 from mouse and similar proteins from vertebrates. PARP14 is an ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins []. It is related to inhibition of STAT1 phosphorylation, however it has been suggested that this may be the result of sumoylation of STAT1 'Lys-703' [].WWE domains are characterised by the presence of a Trp-Trp-Glu region, which is important for the structure stabilisation of PARP14. WWE domains can bind to ADP-Ribose derivatives, including iso-ADP-ribose, a molecule specifically found in PAR and promote interactions with ubiquitinated proteins. The PARP14 WWE domain, however, is unable to bind to any ADP-ribose derivatives and whether it interacts with iso-ADP ribose or ubiquitinated targets is unknown. |
