| Primary Identifier | IPR054519 | Type | Domain |
| Short Name | INTS7_C |
| description | This entry represents the C-terminal domain of the Integrator complex subunit 7 (INTS7).Integrator complex subunit 7 (INTS7) is a component of the integrator complex which is recruited to the U1 and U2 snRNA genes and mediates the snRNAs' 3' end processing. The integrator complex interacts with the C-terminal tail of the largest subunit of RNA-polymerase II to promote 3'-snRNA processing []. INTS7 interacts with INTS1 and INTS2 making extensive contacts with each other, nucleating the assembly of the whole INTAC complex []. In zebrafish, C. elegans and Drosophila, INTS7 has been found to be essential for normal development [, , , ]. |
