| Primary Identifier | IPR064532 | Type | Domain |
| Short Name | PDZ9_MUPP1 |
| description | Multiple PDZ domain protein (MUPP1) and PATJ serve as scaffolding proteins linking different proteins and protein complexes involved in the organisation of tight junctions and epithelial polarity. MUPP1 contains an L27 (Lin-2 and Lin-7 binding) domain and 13 PDZ domains. MUPP1 and PATJ share several binding partners, including junctional adhesion molecules (JAM), zonula occludens (ZO)-3, Pals1 (protein associated with Lin-7), Par (partitioning defective)-6 proteins, and nectins (adherence junction adhesion molecules) [, , , , , , ]. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by ��-strands. This entry represents the ninth PDZ domain (PDZ9) which is a canonical PDZ domain containing six ��-strands A-F and two ��-helices (��-helix 1 and 2), arranged in the order: ��-strands A, B, C, ��-helix 1, ��-strands D, E, ��-helix 2 and ��-strand F. |
