| Primary Identifier | IPR050884 | Type | Family |
| Short Name | CNP_phosphodiesterase-III |
| description | The cyclic nucleotide phosphodiesterase class-III family encompasses enzymes that hydrolyze cyclic nucleotides to their corresponding monophosphates, thus playing a crucial role in regulating intracellular concentrations of cyclic AMP (cAMP) and cyclic GMP (cGMP). These enzymes modulate cAMP-dependent pathways, influencing responses to nutritional stress and virulence factor regulation in various organisms. Some family members exhibit dual specificity for cAMP and cGMP, while others preferentially hydrolyze glycerophosphodiesters, indicating a broader substrate specificity. The activity of these phosphodiesterases is regulated by divalent metal ions such as Ca(2+), Mg(2+), and Mn(2+), with some also being influenced by the presence of transition-metal ions or activated by iron. The family includes enzymes with a C-terminal extension that adjusts substrate alignment in the active site and affects subcellular localization and expression levels. |
