| Primary Identifier | IPR047401 | Type | Domain |
| Short Name | FH_FOXN1 |
| description | This entry represents the forkhead (FH) domain of human FOXN1 and similar sequences from vertebrates. The FH domain is a winged helix DNA-binding domain.Forkhead box protein N1 (FOXN1) acts as a transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) [, ], both in the prenatal and postnatal thymus [, , , ]. Loss of function of this transcription factor leads to the human counterpart of the nude mouse characterised by athymia with severe T cell immunodeficiency, congenital alopecia, and nail dystrophy []. It has been reported that FOXN1 duplication leads to congenital hypertrichosis []. It is also an important factor in controlling the skin wound healing process, as it actively participates in re-epithelialization and is responsible for scar formation [, ]. |
