| Primary Identifier | IPR049789 | Type | Family |
| Short Name | ArsI/CadI-like |
| description | This entry includes Trivalent organoarsenical cleaving enzyme from Thermomonospora curvata (ArsI), Cadmium-induced protein CadI from Mycobacterium tuberculosis, and related bacterial proteins. ArsI is a nonhaeme iron-dependent dioxygenase that can break carbon-arsenic bonds, playing a role in the detoxification of environmental organoarsenical compounds. It catalyses the oxygen-dependent demethylation of highly toxic methylarsonous acid (MAs(III)) to arsenite, which can then be exported out of the cell [, ]. Proteins in this entry contain a VOC (Vicinal Oxygen Chelate) domain (). Members of this family have an invariant CC sequence motif at about position 95, and have poorly conserved C-terminal regions that frequently contain at least one addition CC motif []. |
