| Primary Identifier | IPR050927 | Type | Family |
| Short Name | TRPM_cation_chan |
| description | Members of the transient receptor potential cation channel subfamily M (TRPM) are voltage-independent, non-selective or monovalent-selective cation channels that mediate the influx of ions such as Ca(2+), Mg(2+), Na(+), and Zn(2+) [, , ]. They assemble as homotetramers or heterotetramers and are involved in a wide array of physiological processes [, ]. For instance, TRPM8 is a cold sensor activated by low temperatures and cooling agents like menthol [, ], while TRPM4 and TRPM5 are Ca(2+)-activated monovalent cation channels involved in membrane depolarization, with TRPM5 playing a key role in sweet, bitter, and umami taste transduction [, , ]. TRPM1 is essential for the depolarizing photoresponse of retinal ON bipolar cells []. TRPM2 is gated by intracellular ADP-ribose and oxidative stress, contributing to cell death susceptibility and immune responses [, ]. Uniquely, TRPM6 and TRPM7 are 'chanzymes' that possess an intrinsic C-terminal ��-kinase domain, playing crucial roles in organismal Mg(2+) homeostasis and embryonic development [, , ]. |
