| Primary Identifier | IPR021090 | Type | Domain |
| Short Name | SPIDER |
| description | This entry represents the SLy proteins associated disordered region (SPIDER), which is conserved in the SLy protein family. It has a disordered nature and ranges from 143 to 154 residues long. The region includes a conserved LGKK motif of unknown function as well as a nuclear localisation sequence [, , , ]. In most members of this group of proteins from vertebrates, this region is followed by SH3 () and SAM () domains, suggesting a role in the signalling function of these proteins []. SPIDER is a part of the SASH1 protein that plays essential roles in tumour cell adhesion and migration []. Multiple disease variants in the SPIDER of SASH1 suggest that it may be involved in the regulation of skin pigmentation []. |
