| Primary Identifier | IPR045852 | Type | Domain |
| Short Name | UNC80_central |
| description | This entry represents the central region of protein UNC80 from eukaryotes, a component of the NALCN sodium channel complex. Proteins containing this domain also include some uncharacterised proteins from fungi.UNC80 is a protein associated with the NALCN sodium channel complex. NALCN is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79, and both are key regulators of the channel and required for the proper expression and axonal localisation of NALCN. UNC80 is required for NALCN control by GPCRs and is essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for the Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN [, , ].UNC80 is required for the activation of the NALCN channel by the neuropeptide substance P. NALCN activation is G-protein-independent but requires Src kinases: UNC80 binds Src kinases and recruits Src into the channel complex []. UNC80 is also required for the proper localisation of C. elegans NCA-1 and NCA-2, the homologues of the vertebrate cation leak channel NALCN [], and NCA-1 and UNC-80 regulate neuronal activity in C. elegans []. |
