| Primary Identifier | IPR065089 | Type | Domain |
| Short Name | MPDZ_PATJ_PDZ1 |
| description | This entry represents the first PDZ domain (PDZ1) found in multi-PDZ domain protein (MPDZ, also known as MUPP1) and protein associated to tight junctions (PATJ, also known as InaD-like protein). Both MPDZ and PATJ are scaffolding proteins that facilitate the localisation of various proteins to the cell membrane and are required for the correct formation of tight junctions [, ]. These host proteins typically share a similar domain architecture, consisting of an N-terminal L27 domain followed by multiple PDZ domains. In MPDZ, this specific first PDZ domain has been shown to interact with the membrane-spanning proteoglycan NG2 [, ]. |
