| Primary Identifier | IPR065095 | Type | Domain |
| Short Name | L3MBTL3_MBT3 |
| description | This entry represents the third malignant brain tumour (MBT) unit found in lethal(3)malignant brain tumour-like protein 3 (L3MBTL3). L3MBTL3 acts as a negative regulator of Notch target gene expression and is required for RBPJ-mediated transcriptional repression []. It is also involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 [, ]. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins. L3MBTL3 typically contains three MBT units, along with a SAM domain and a C2H2C-type zinc finger [, , ]. |
