| Primary Identifier | IPR065094 | Type | Domain |
| Short Name | L3MBTL3_MBT1 |
| description | This entry represents the first malignant brain tumour (MBT) unit found in Lethal(3)malignant brain tumour-like protein 3 (L3MBTL3) from vertebrates. L3MBTL3 acts as a negative regulator of Notch target gene expression and is required for RBPJ-mediated transcriptional repression []. It functions by recruiting the histone demethylase KDM1A to Notch-responsive elements, promoting H3K4me demethylation []. Furthermore, L3MBTL3 regulates the ubiquitin-dependent degradation of methylated non-histone proteins, including SOX2, DNMT1, and E2F1, acting as an adapter that recruits the CRL4-DCAF5 E3 ubiquitin ligase complex to these methylated targets [, ]. L3MBTL3 is also essential for the normal maturation of myeloid progenitor cells [, , , , , ]. This entry typically co-occurs with two other MBT units, a C2H2C-type zinc finger, and a sterile alpha motif (SAM) domain. |
