| Primary Identifier | IPR051066 | Type | Family |
| Short Name | CoREST |
| description | This family comprises the REST corepressor (CoREST) proteins, as well as related transcriptional regulators such as zinc finger protein 541 (ZNF541), mitotic deacetylase-associated SANT domain protein (MIDEAS), and transcriptional-regulating factor 1 (TRERF1). Members of this family typically function as components of histone deacetylase (HDAC) complexes to regulate gene expression. For example, mammalian RCOR1 (CoREST) is an essential component of the BHC complex, which represses the transcription of neuron-specific genes in non-neuronal cells by deacetylating and demethylating specific sites on histones [, , ]. ZNF541 is a component of an HDAC complex that regulates the progression of the pachytene stage of meiotic prophase during spermatogenesis [, ]. MIDEAS is a component of the MiDAC histone deacetylase complex []. TRERF1 interacts with CREBBP and EP300 to activate the transcription of specific genes []. These proteins typically share a conserved domain architecture that includes an ELM2 domain and one or more SANT domains, which mediate protein-protein interactions and nucleosome binding [, ]. |
