| Primary Identifier | IPR051381 | Type | Family |
| Short Name | CREB3_family |
| description | This family includes the cyclic AMP-responsive element-binding protein 3 (CREB3) and related proteins such as CREB3L3 and CREB3L4, as well as the Caenorhabditis elegans homologue let-607. These proteins are endoplasmic reticulum (ER)-bound sequence-specific transcription factors that belong to the basic-leucine zipper (bZIP) family. They are activated by regulated intramembrane proteolysis (RIP) in response to ER stress, releasing a transcriptionally active N-terminal fragment that translocates to the nucleus to activate unfolded protein response (UPR) target genes [, ]. They bind to the cAMP response element (CRE) and other regulatory elements to modulate genes involved in cell survival, lipid metabolism, and inflammatory responses [, , , ]. |
