| Primary Identifier | IPR051725 | Type | Family |
| Short Name | SASH_SAMSN1 |
| description | This family comprises SAM and SH3 domain-containing proteins, including SASH1, SASH3, SAMSN1 (also known as HACS1 or SLy2), and SAMD5. These proteins primarily function as signalling adaptors or scaffold molecules in various cellular processes. SASH1 acts as a scaffold that positively regulates NF-kappa-B signalling downstream of TLR4 activation, and is involved in cellmigration and skin pigmentation [, ]. It also interacts with Eph receptors []. SAMSN1 is a negative regulator of B-cell activation and promotes RAC1-dependent membrane ruffle formation and actin cytoskeleton reorganization [, , ]. SASH3 functions as a signalling adapter protein in lymphocytes []. SAMD5 interacts with Eph receptors via its SAM domain []. Members of this family typically contain a Src homology 3 (SH3) domain and one or more sterile alpha motif (SAM) domains, which mediate protein-protein interactions. |
