| Primary Identifier | IPR022145 | Type | Domain |
| Short Name | INTS1_RPB2-bd |
| description | Integrator (INT) complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing []. It binds the C-terminal domain (CTD) of RNA polymerase II (Pol II) and functions as an RNA endonuclease to cleave different classes of RNAs, regulating the transcription of both protein-coding genes and noncoding elements [, ]. Integrator also associates with protein phosphatase 2A (PP2A) core enzyme to form the INTAC complex [, ]which regulates transcription through dephosphorylation of Pol II CTD. The complex consists of four modules: the backbone, the shoulder, the phosphatase and the endonuclease, formed by different integrator components.This entry includes the Integrator complex subunit 1 (INTS1) which forms the backbone module of the complex through the association with INTS2 and INTS7 to form a rigid scaffold. The backbone and shoulder modules form a central cruciform scaffold. INTS1 is an all-�� helical protein with four repetitive helix hairpin domains towards the C-terminal (R1-R4) [, ]. This entry represents a domain found towards the N-terminal region, which interacts with Pol II subunit RPB2 and form interface A []. |
