| Primary Identifier | IPR056517 | Type | Domain |
| Short Name | INTS7_HB |
| description | This entry represents the helical bundle (HB) of INTS7, localised between the superhelical ��-solenoid () and the C-terminal ��-sandwich () [].Integrator complex subunit 7 (INTS7) is a component of the integrator complex which is recruited to the U1 and U2 snRNA genes and mediates the snRNAs' 3' end processing. The integrator complex interacts with the C-terminal tail of the largest subunit of RNA-polymerase II to promote 3'-snRNA processing []. INTS7 interacts with INTS1 and INTS2 making extensive contacts with each other, nucleating the assembly of the whole INTAC complex []. In zebrafish, C. elegans and Drosophila, INTS7 has been found to be essential for normal development[, , , ]. |
