| Primary Identifier | IPR056597 | Type | Domain |
| Short Name | ARM_LRRK2 |
| description | This entry represents the armadillo repeat (ARM) found at the N-terminal end of Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) from eukaryotes. The domain adopts an ARM-like fold, consisting of a right-handed superhelix formed by two curved layers of repeated helical structural units []. A patch of negatively charged residues within the ARM domain has been pointed to contribute to complex formation by binding a positive residue in Rab switch 1 region [, , ]. ARM domain is also suggested to form connections between adjacent microtubules []. Also included in this entry is the armadillo repeat domain of Protein aardvark from Dictyostelium discoideum, a component of the junctional complex, both involved in cell adhesion and signalling [].LRRK2 is a serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, primary ciliogenesis, autophagy, and vesicle trafficking [, , , ]. Mutations in LRRK2 are the most common genetic cause of Parkinson's disease []. LRRK2 phosphorylates a group of Rab GTPase proteins, including Rab29. |
