| Primary Identifier | IPR056484 | Type | Domain |
| Short Name | PHD_P300 |
| description | This domain is found in human Histone acetyltransferase p300 (EP300), Histone lysine acetyltransferase CREBBP and similar animal proteins. EP300 functions as a histone acetyltransferase and regulates transcription via chromatin remodelling [, ]. Histone lysine acetyltransferase CREBBP acetylates histones, giving a specific tag for transcriptional activation [, ]. It mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively) []. CREBBP also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 [, ].This entry represents the PHD domain, which forms a module with the bromodomain () and the RING domain () that associates intimately with the HAT domain () through numerous conserved contacts []. |
