| Primary Identifier | IPR056993 | Type | Domain |
| Short Name | TRIP4_3rd_dom |
| description | This entry represents a presumed domain found in Activating signal cointegrator 1 (TRIP4, also known as ASC-1) from human and related sequences from animals and some plant species. The function of this domain is unknown.TRIP4 is the orthologue of yeast RQT4 and is part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation [, , ]. TRIP4 has also been described as a transcription coactivator which associates with nuclear receptors and transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription [, ]. |
