| Primary Identifier | IPR056994 | Type | Domain |
| Short Name | TRI4_N |
| description | This entry represents a presumed domain found at the N-terminal of Activating signal cointegrator 1 (TRIP4, also known as ASC-1) from human and related animal sequences. The function of this domain is unknown. According to structure predictions, this domain may adopt a four helical bundle fold.TRIP4 is the orthologue of yeast RQT4 and is part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation [, , ]. TRIP4 has also been described as a transcription coactivator which associates with nuclear receptors and transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription [, ]. |
