| Primary Identifier | IPR047836 | Type | Domain |
| Short Name | GPR174_7tmA |
| description | This entry represents the seven transmembrane segments of G-protein coupled receptor 174 (GPR174).GPR174 has been identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation [, ]. It is involved in the immune response and has been linked to autoimmune diseases [, ]. GPR174 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands []. A general feature of GPCR signalling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes [, , , , , ]. |
