| Primary Identifier | IPR056885 | Type | Domain |
| Short Name | TPR_NPHP3 |
| description | This entry represents a tetratricopeptide repeats (TPR) region found at the nephrocystin-3 (NPHP3) and related proteins from animals.NPHP3 is a protein required for normal ciliary development and function. It inhibits disheveled-1-induced canonical Wnt-signalling activity and may also play a role in the control of non-canonical Wnt signalling which regulates planar cell polarity []. Loss of the NPHP3 function results in situs inversus, congenital heart defects, and embryonic lethality in mice []. |
