| Primary Identifier | IPR056886 | Type | Domain |
| Short Name | NPHP3_ab_dom |
| description | This domain is found in human Nephrocystin-3 (NPHP3) and similar animal proteins. This domain is predicted to show a ��-sheet with ��-helices at both sides.NPHP3 is a protein required for normal ciliary development and function. It inhibits disheveled-1-induced canonical Wnt-signalling activity and may also play a role in the control of non-canonical Wnt signalling which regulates planar cell polarity []. Loss of the NPHP3 function results in situs inversus, congenital heart defects, and embryonic lethality in mice []. |
