| Primary Identifier | IPR052109 | Type | Family |
| Short Name | SRRM |
| description | This family consists of serine/arginine repetitive matrix proteins (SRRM), including SRRM2, SRRM3, and SRRM4, which are found primarily in eukaryotes. They function as RNA splicing factors that regulate alternative splicing and are components of the spliceosome. SRRM2 is required for pre-mRNA splicing and is a component of the minor spliceosome, which splices U12-type introns. SRRM3 and SRRM4 regulate the inclusion of microexons in mRNA transcripts and are essential for neural cell differentiation, motor coordination, and nervous system development [, , , , , , ]. In cortical neurons, SRRM3 and SRRM4 act redundantly to regulate alternative splicing events, such as the inactivation of the transcriptional repressor REST []. SRRM3 also mediates microexon inclusion in pancreatic islets, regulating insulin and glucagon secretion []. |
