| Primary Identifier | IPR052586 | Type | Family |
| Short Name | ASCC2 |
| description | This family represents the activating signal cointegrator 1 complex subunit 2 (ASCC2), also known as ASC-1 complex subunit p100, and its yeast orthologue CUE3 (also known as RQT3). ASCC2 is a ubiquitin-binding protein involved in DNA repair and the rescue of stalled ribosomes [, , , ]. In mammals, it plays a role in DNA damage repair as a component of the ASCC complex, recruiting ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins []. It is also part of the ASC-1 complex that enhances NF-kappa-B, SRF, and AP1 transactivation []. Furthermore, ASCC2 and CUE3 are involved in the activation of the ribosome quality control (RQC) pathway, which degrades nascent peptide chains during problematic translation. They specifically recognise and bind ubiquitinated RPS20/uS10, promoting the recruitment of the RQT (ribosome quality control trigger) complex to stalled ribosomes, followed by their disassembly [, , ]. The interaction with ubiquitin is mediated by a CUE domain []. |
