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Protein Domain : Nucleotide metabolism enzyme

Primary Identifier  IPR052968 Type  Family
Short Name  Nucleotide_metab_enz
description  This family of prokaryotic proteins includes enzymes involved in nucleotide metabolism. Some members of this family are capable of degrading RNA oligonucleotides, particularly those with a length of five nucleotides, by cleaving them from the 3' to 5' direction. They exhibit a preference for adenine-rich RNA sequences and show reduced activity on shorter oligonucleotides or those with a length of 24 nucleotides []. Additionally, some family members possess the ability to hydrolyse cyclic nucleotides such as cAMP and cGMP into their corresponding 5'-monophosphates, without exhibiting phosphohydrolase activity towards phospholipids or phosphorylated sugars []. The enzymatic activities of these proteins are crucial for the regulation of intracellular nucleotide levels and the maintenance of RNA turnover.

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0 Protein Domain Regions