| Primary Identifier | IPR052994 | Type | Family |
| Short Name | TmcB_TmcC |
| description | This family includes Tiny macrocysts protein B (TmcB) and C (TmcC) from the social amoeba Dictyostelium discoideum, as well as related proteins from other eukaryotes. TmcB is a multi-pass membrane protein that acts as a regulator of the cAMP signalling pathway specific to sexual development. It controls the levels of external cAMP by regulating the expression of phosphodiesterase pdsA and its inhibitor pdiA []. TmcC is also a multi-pass membrane protein involved in sexual development, though its disruption does not affect the cAMP response []. Members of this family often contain PAS domains and tetratricopeptide (TPR) repeats. |
