| Primary Identifier | IPR057049 | Type | Domain |
| Short Name | PARP14_KH_8 |
| description | This domain is found in human Protein mono-ADP-ribosyltransferase PARP14 and related proteins including mono-ADP-ribosyltransferase PARP9. It is a KH domain found eighth in PARP14.PARP14 is a large multidomain protein which in the N-terminal half contains a series of consecutive RRM and KH domains that are known to be nucleic acid-binding. PARP14 is involved in multiple signaling pathways linked to cancer, inflammation, and infection. PARP14 is an ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins [, , ]. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation [].PARP9 in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses []. It suppresses PARP14-mediated STAT6 ADP-ribosylation []. During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 []. PARP9 is a multidomain protein, predicted to contain only a single KH domain. |
