| Primary Identifier | IPR057333 | Type | Domain |
| Short Name | SEA_Gpr126 |
| description | This entry represents the Sperm protein, Enterokinase and Agrin (SEA) domain found in the adhesion G protein-coupled receptor Gpr126/ADGRG6 from vertebrates. The domain adopts a ferredoxin-like ��/�� sandwich fold []and is located between the PTX and HormR domains in the extracellular region. In human GPR126, this domain contains a furin cleavage site that is conserved in many mammals and birds []. After cleavage, the domain remains intact until mechanical force causes separation, similar to SEA domains in other proteins like Mucins and Notch. The SEA domain plays a role in regulating receptor function through proteolytic processing and mechanical force sensing.The mouse member is involved in many biological processes, such as myelination, sprouting angiogenesis, placenta, ear and cartilage development [, , , , ]. It also acts as a regulator of body length and bone mass []and as a regulator of blood-brain barrier formation in the central nervous system via its association with LRP1 and ITGB1 []. |
