| Primary Identifier | IPR057848 | Type | Domain |
| Short Name | WDR72_alpha-sol |
| description | This entry represents an ��-solenoid domain found in WDR72. This entry also includes WDR7, whose function is currently unknown.WD repeat-containing protein 72 (WDR72) plays a major role in the formation of tooth enamel, particularly during the maturation phase of amelogenesis, where it is essential for normal enamel matrix formation and the clearance of enamel proteins [, ]. WDR72 may also be involved in the localisation of the calcium transporter SLC24A4 to the ameloblast cell membrane. These proteins share a distinct domain architecture comprising one or two ��-propellers followed by an ��-solenoid domain , an evolutionarily conserved structure common among proteins that form membrane coat complexes, dating back to the early eukaryotic endomembrane system []. |
