| First Author | Nguyen HT | Year | 2024 |
| Journal | Nat Immunol | Volume | 25 |
| Issue | 9 | Pages | 1718-1730 |
| PubMed ID | 39025963 | Mgi Jnum | J:361561 |
| Mgi Id | MGI:7859572 | Doi | 10.1038/s41590-024-01910-0 |
| Citation | Nguyen HT, et al. (2024) Galpha13 restricts nutrient driven proliferation in mucosal germinal centers. Nat Immunol 25(9):1718-1730 |
| abstractText | Germinal centers (GCs) that form in mucosal sites are exposed to gut-derived factors that have the potential to influence homeostasis independent of antigen receptor-driven selective processes. The G-protein Galpha13 confines B cells to the GC and limits the development of GC-derived lymphoma. We discovered that Galpha13-deficiency fuels the GC reaction via increased mTORC1 signaling and Myc protein expression specifically in the mesenteric lymph node (mLN). The competitive advantage of Galpha13-deficient GC B cells (GCBs) in mLN was not dependent on T cell help or gut microbiota. Instead, Galpha13-deficient GCBs were selectively dependent on dietary nutrients likely due to greater access to gut lymphatics. Specifically, we found that diet-derived glutamine supported proliferation and Myc expression in Galpha13-deficient GCBs in the mLN. Thus, GC confinement limits the effects of dietary glutamine on GC dynamics in mucosal tissues. Galpha13 pathway mutations coopt these processes to promote the gut tropism of aggressive lymphoma. |
