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CL Term : subepithelial intestinal fibroblast [CL:4052007] Cell Ontology
Obsolete  false
description  A fibroblast located adjacent to the intestinal epithelium in both the small intestine and colon, specifically around the crypts. This cell is characterized by the expression of PDGFRα and various collagen isoforms, including COL4A5 and COL4A6. It secretes signalling molecules like TGF-β, Wnt ligands, and BMPs, which are crucial for epithelial homeostasis, intestinal stem cell support, and basement membrane formation.
  • synonyms:
  • S2 mesenchymal cells,
  • S2 fibroblast
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