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CL Term : crypt-top fibroblast [CL:4052009] Cell Ontology
Obsolete  false
description  A subepithelial intestinal fibroblast that is located adjacent to the top of the crypt of Lieberkuhn. Characterized by high experession of PDGFRα, this cell secretes a range of signaling factors, including WNTs and BMPs, that drive epithelial differentiation, creating a gradient that regulates the balance between stem cell maintenance and differentiation.
  • synonyms:
  • top pericryptic fibroblast,
  • CTFs,
  • S2b fibroblast
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