| First Author | Nesbitt M | Year | 1990 |
| Journal | Mouse Genome | Volume | 88 |
| Pages | 113 | Mgi Jnum | J:17659 |
| Mgi Id | MGI:65690 | Citation | Nesbitt M, et al. (1990) Strain distribution pattern of thirteen genetic loci in the AXB and BXA recombinant inbred set. Mouse Genome 88:113 |
| abstractText | Full text of Mouse Genome contribution: STRAIN DISTRIBUTION PATTERN OF THIRTEEN GENETIC LOCI IN THE AXB AND BXA RECOMBINANT INBRED SET. M. Nesbitt (1), S.L. Pugh (2) and B. Paigen (2). (1) University of California, San Diego, La Jolla, CA 92093 and (2) The Jackson Laboratory, Bar Harbor, ME 04609. INTRODUCTION One of the most useful tools in mammalian genetics for mapping genes is recombinant inbred (RI) strains (1). The AXB and BXA RI set was developed by Nesbitt using reciprocal crosses of the progenitors C57BL/6J and A/J (2). We report the strain distribution patterns for thirteen loci in this RI set. MATERIALS AND METHODS Loci were typed by the following methods: Car-2, carbonic anhydrase-2 (3); Mup-1, major urinary protein (4); Akp-2, alkaline phosphatase-2 (5); b, brown using breeding tests for albino strains (6); Gpd-1, glucose phosphate dehydrogenase-1 (7); Gus-s, beta-glucuronidase structural (8); Ggc, gamma glutamyl cyclotransferase (9); Gpi-1, glucose phosphate isomerase-1 (10); Tam-1, tosyl arginine methyl esterase-1 (11); c, albino (6); Hbb, hemoglobin beta chain (12); Es-3, esterase-3 (13); and Np-2, nucleoside phosphorylase-2 (14). RESULTS AND DISCUSSION The strain distribution pattern of the thirteen loci is shown in Table 1. All these loci have already been mapped and some are considered anchor loci. The addition of these loci will improve the usefulness of this set for mapping new genes whose map position is currently unknown. Table 1. Strain Distribution Pattern of Loci at AXB and BXA Recombinant Inbred Set.* Locus: Car-2; Chr: 3; Allele: A/J: b; B6: a; AXB: 1: B; 2: B; 3: A; 4: A; 5: A; 6: B; 7: A; 8: B; 9: A; 10: B; 11: A; 12: B; 13: A; 14: A; 15: A; 16: -; 17: B; 18: B; 19: B; 20: B; 21: -; 22: B; 23: B; 24: B; 25: A; BXA: 1: A; 2: A; 3: A; 4: B; 5: -; 6: A; 7: B; 8: A; 9: A; 10: -; 11: B; 12: A; 13: A; 14: B; 15: B; 16: B; 17: A; 18: A; 19: -; 20: -; 21: -; 22: A; 23: A; 24: B; 25: B. Locus: Mup-1; Chr: 4; Allele: A/J: a; B6: b; AXB: 1: B; 2: A; 3: B; 4: B; 5: A; 6: B; 7: B; 8: A; 9: -; 10: B; 11: A; 12: B; 13: A; 14: B; 15: B; 16: -; 17: A; 18: -; 19: B; 20: B; 21: B; 22: A; 23: B; 24: B; 25: A; BXA: 1: A; 2: A; 3: -; 4: A; 5: -; 6: A; 7: A; 8: B; 9: A; 10: B; 11: -; 12: A; 13: A; 14: B; 15: -; 16: A; 17: B; 18: A; 19: A; 20: A; 21: -; 22: A; 23: B; 24: A; 25: B. Locus: Akp-2; Chr: 4; Allele: A/J: a; B6: b; AXB: 1: A; 2: A; 3: -; 4: B; 5: -; 6: B; 7: B; 8: -; 9: B; 10: B; 11: B; 12: B; 13: -; 14: -; 15: -; 16: -; 17: -; 18: -; 19: B; 20: A; 21: B; 22: A; 23: B; 24: A; 25: B; BXA: 1: B; 2: A; 3: -; 4: A; 5: -; 6: B; 7: B; 8: A; 9: A; 10: -; 11: -; 12: B; 13: B; 14: -; 15: -; 16: B; 17: -; 18: B; 19: A; 20: -; 21: B; 22: B; 23: B; 24: B; 25: b. Locus: b; Chr: 4; Allele: A/J: b; B6: +; AXB: 1: B; 2: A; 3: B; 4: B; 5: A; 6: A; 7: B; 8: A; 9: B; 10: B; 11: A; 12: B; 13: A; 14: A; 15: B; 16: A; 17: A; 18: B; 19: B; 20: ; 21: A; 22: A; 23: B; 24: B; 25: A; BXA: 1: A; 2: A; 3: B; 4: A; 5: B; 6: A; 7: A; 8: B; 9: A; 10: -; 11: B; 12: A; 13: A; 14: B; 15: -; 16: A; 17: B; 18: -; 19: -; 20: A; 21: -; 22: B; 23: A; 24: B; 25: A. Locus: GPD-1; Chr: 4; Allele: A/J: a; B6: b; AXB: 1: B; 2: B; 3: B; 4: B; 5: A; 6: A; 7: A; 8: B; 9: B; 10: A; 11: B; 12: A; 13: B; 14: B; 15: B; 16: B; 17: B; 18: A; 19: A; 20: B; 21: B; 22: -; 23: A; 24: A; 25: B; BXA: 1: B; 2: B; 3: A; 4: B; 5: B; 6: A; 7: B; 8: B; 9: A; 10: B; 11: A; 12: A; 13: B; 14: B; 15: A; 16: A; 17: B; 18: B; 19: B; 20: B; 21: A; 22: A; 23: A; 24: B; 25: A. Locus: Gus-s; Chr: 5; Allele: A/J: a; B6: b; AXB: 1: B; 2: A; 3: B; 4: B; 5: A; 6: A; 7: B; 8: B; 9: A; 10: A; 11: B; 12: A; 13: B; 14: B; 15: -; 16: -; 17: A; 18: A; 19: A; 20: B; 21: A; 22: A; 23: A; 24: A; 25: B; BXA: 1: A; 2: A; 3: B; 4: A; 5: B; 6: B; 7: A; 8: -; 9: B; 10: A; 11: A; 12: A; 13: B; 14: B; 15: A; 16: A; 17: A; 18: B; 19: A; 20: A; 21: A; 22: B; 23: B; 24: B; 25: B. Locus: Ggc; Chr: 6; Allele: A/J: a; B6: b; AXB: 1: B; 2: B; 3: A; 4: B; 5: A; 6: A; 7: A; 8: B; 9: A; 10: A; 11: B; 12: A; 13: B; 14: B; 15: B; 16: -; 17: A; 18: B; 19: -; 20: -; 21: B; 22: -; 23: A; 24: B; 25: A; BXA: 1: A; 2: B; 3: A; 4: A; 5: A; 6: B; 7: A; 8: -; 9: A; 10: -; 11: A; 12: A; 13: A; 14: B; 15: A; 16: A; 17: -; 18: A; 19: B; 20: A; 21: -; 22: A; 23: A; 24: A; 25: -. Locus: Gpi-1; Chr: 7; Allele: A/J: a; B6: b; AXB: 1: B; 2: A; 3: A; 4: B; 5: A; 6: A; 7: A; 8: B; 9: A; 10: B; 11: A; 12: A; 13: A; 14: A; 15: A; 16: A; 17: A; 18: B; 19: B; 20: B; 21: A; 22: B; 23: B; 24: B; 25: A; BXA: 1: B; 2: A; 3: B; 4: A; 5: B; 6: A; 7: A; 8: A; 9: A; 10: A; 11: A; 12: A; 13: A; 14: B; 15: -; 16: B; 17: A; 18: B; 19: B; 20: A; 21: A; 22: B; 23: A; 24: A; 25: A. Locus: Tam-1; Chr: 7; Allele: A/J: a; B6: b; AXB: 1: B; 2: B; 3: A; 4: B; 5: A; 6: A; 7: B; 8: B; 9: A; 10: B; 11: A; 12: A; 13: B; 14: A; 15: A; 16: -; 17: A; 18: A; 19: B; 20: A; 21: A; 22: A; 23: A; 24: B; 25: B; BXA: 1: B; 2: A; 3: B; 4: A; 5: B; 6: A; 7: B; 8: B; 9: B; 10: -; 11: A; 12: B; 13: A; 14: A; 15: A; 16: B; 17: A; 18: B; 19: B; 20: -; 21: A; 22: A; 23: A; 24: A; 25: A. Locus: c; Chr: 7; Allele: A/J: c; B6: +; AXB: 1: B; 2: A; 3: A; 4: B; 5: B; 6: A; 7: B; 8: B; 9: A; 10: B; 11: A; 12: A; 13: A; 14: A; 15: B; 16: B; 17: B; 18: B; 19: B; 20: B; 21: B; 22: A; 23: B; 24: B; 25: B; BXA: 1: B; 2: A; 3: B; 4: A; 5: B; 6: B; 7: A; 8: B; 9: A; 10: A; 11: B; 12: B; 13: A; 14: A; 15: A; 16: A; 17: B; 18: A; 19: A; 20: A; 21: A; 22: A; 23: A; 24: A; 25: B. Locus: Hbb; Chr: 7; Allele: A/J: d; B6: s; AXB: 1: B; 2: A; 3: A; 4: B; 5: A; 6: A; 7: B; 8: B; 9: A; 10: B; 11: B; 12: A; 13: A; 14: A; 15: B; 16: -; 17: B; 18: B; 19: B; 20: B; 21: B; 22: A; 23: A; 24: B; 25: B; BXA: 1: B; 2: B; 3: B; 4: A; 5: B; 6: B; 7: A; 8: B; 9: A; 10: A; 11: A; 12: B; 13: A; 14: A; 15: A; 16: B; 17: B; 18: A; 19: A; 20: A; 21: A; 22: A; 23: A; 24: B; 25: B. Locus: Es-3; Chr: 11; Allele: A/J: c; B6: a; AXB: 1: B; 2: B; 3: A; 4: A; 5: A; 6: B; 7: A; 8: B; 9: A; 10: B; 11: A; 12: A; 13: A; 14: B; 15: B; 16: -; 17: B; 18: B; 19: B; 20: B; 21: B; 22: B; 23: A; 24: A; 25: -; BXA: 1: B; 2: A; 3: B; 4: B; 5: A; 6: B; 7: B; 8: A; 9: B; 10: -; 11: A; 12: B; 13: B; 14: B; 15: A; 16: A; 17: A; 18: A; 19: B; 20: A; 21: B; 22: B; 23: A; 24: B; 25: A. Locus: Np-2; Chr: 14; Allele: A/J: a; B6: b; AXB: 1: B; 2: A; 3: B; 4: A; 5: B; 6: A; 7: A; 8: B; 9: A; 10: B; 11: B; 12: B; 13: B; 14: B; 15: -; 16: -; 17: B; 18: B; 19: B; 20: B; 21: B; 22: B; 23: A; 24: B; 25: -; BXA: 1: B; 2: B; 3: -; 4: A; 5: -; 6: A; 7: A; 8: A; 9: B; 10: A; 11: -; 12: B; 13: A; 14: A; 15: -; 16: A; 17: A; 18: -; 19: B; 20: A; 21: -; 22: A; 23: A; 24: A; 25: A. *B6 refers to strain C57BL/6J. In the strain distribution pattern A refers to A-like and B to C57BL/6 like. ACKNOWLEDGEMENTS: This work was supported by NIH Grant No. HL32087. REFERENCES 1. Taylor (1978) Origins of Inbred Mice, H.C. Morse III, ed. Academic Press, N.Y. p. 423. 2. Nesbitt & Skamene (1984) J. Leuk. Biol. 36:357. 3. Eicher et al. (1976) Biochem. Genet. 14:651. 4. Hoffman (1970) Proc. Soc. Exp. Biol. Med. 135:81. 5. Wilcox & Taylor (1981) Genet. 17:1093. 6. Markert & Silvers (1956) Genet. 41:429. 7. Ruddle et al. (1968) 58:599. 8. Ganschow & Bunker (1970) Biochem. Genet. 4:127. 9. 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