| First Author | Meistrich ML | Year | 1990 |
| Journal | Mouse Genome | Volume | 86 |
| Pages | 258 | Mgi Jnum | J:14286 |
| Mgi Id | MGI:62457 | Citation | Meistrich ML, et al. (1990) Mapping of azh. Mouse Genome 86:258 |
| abstractText | Full text of Mouse Genome contribution: Research News: We have been mapping azh (Hugenholz et al. MNL 71: 34 1984), an autosomal, recessive mutation that in homozygous males results in 100% of the sperm having abnormal head shapes. The primary defect in the mutation appears to be in the location within the spermatid where the microtubular manchette forms (Cole et al. Biol. Reprod. 38:385 1988). A backcross was performed breeding azh/azh mice (on a relatively pure C57BL/6 background) with C3H/He and backcrossing male and female offspring to azh/azh. The male progeny were typed for sperm morphology, Gpd-1 (by J. Womack, Texas A & M University), and D4Rpl (using the probe pMK1440 from R. Elliott). The numbers and percentages of recombinants between the three loci are as follows: Gpd-1 vs. azh: 15 / 58 = 26% Gpd-1 vs. Rp1: 14 / 57 = 25% Rpl vs. azh: 3 / 59 = 5% Thus, azh is tightly linked to Rpl, which is on chromosome 4, apparently midway between the centromere and telomere (Huppi et al. Curr. Top. Micro. Immunol. 137: 276 1988). |
