| First Author | Le Tissier P | Year | 1989 |
| Journal | Mouse News Lett | Volume | 84 |
| Pages | 86 | Mgi Jnum | J:14249 |
| Mgi Id | MGI:62421 | Citation | Le Tissier P, et al. (1989) Linkage of adenosine deaminase, Ada. Mouse News Lett 84:86 |
| abstractText | Full text of MNL contribution: Linkage data: 3. Linkage of adenosine deaminase, Ada. Abbott et al. (Proc. Nat. Acad. Sci. 83: 693-695; 1986) suggested that wst was an activity variant of Ada. Our subsequent studies (Abbott et al., submitted, Le Tissier et al., submitted) show that Ada and wst are non-allelic, and Abbott et al. (submitted) have suggested a probable gene order of a ... Ada ... Ra. Further linkage studies have been carried out using an electrophoretic variant of Ada and the data are shown in the Table. Thus the order a ... Ada ... Ra is confirmed; Ada maps close to a; and the RF value in males of 20.2 +/- 3.1% for a-Ra agrees with that previously found.(Green GVSLM 1981). (Le Tissier, Peters and C.J. Skidmore) Table: Recombination between a, Ada and Ra Parental mating: a Ada<a> +/a Ada<a> + female x + Ada<b> Ra/a Ada<a> + male Progeny genotype Progeny class: a; Ada; Ra. Non recombinant: a+; ab; +Ra; Number: 69 aa; aa; ++; Number: 65 Single recombinant: a+; aa; ++; Number: 3 a-Ada: aa; ab; +Ra; Number: 4 Single recombinant: a+; ab; ++; Number: 11 Ada-Ra: aa; aa; +Ra; Number: 16 Total: 168 R.F. (% S.E.) a-Ada: 4.2 +/- 1.5 Ada-Ra: 16.1 +/- 2.8 a-Ra: 20.2 +/- 3.1 |
