| First Author | Karn RC | Year | 1983 |
| Journal | Mouse News Lett | Volume | 68 |
| Pages | 71 | Mgi Jnum | J:30782 |
| Mgi Id | MGI:78367 | Citation | Karn RC (1983) Abpa. Mouse News Lett 68:71 |
| abstractText | Full text of MNL contribution: Research News: In previous publications we described a new mouse gene, Ssp, which controls an androgen induced change in electrophoretic mobility of a mouse salivary protein(Genetics 94:s52, 1980; Biochem. Genet. 20:493-504, 1982). That gene, which is listed among the new gene symbols in this issue of MNL, probably is not the structural gene for the protein affected but rather mediates the androgen dependent alteration in its mobility. Our recent strain surveys indicate that the DBA/2J strain has a variant form of the affected protein. The variant allele in DBA/2J determines a protein with a slower pattern than the Ssp F and S phenotypes in the other strains we have examined. Preliminary genetic and biochemical analyses indicate that the variant allele is inherited as a codominant in the FI from crosses with C3H/St and we have designated the structural gene Tcp (Testosterone controlled protein). The DBA/2J variation appears to affect the isoelectric point of Tcp, supporting the conclusion that the variation is in a structural gene (Fed. Proc., in press, 1983). Recent discussions with Benjamin Taylor at Jackson Laboratory indicate that Tcp may be similar to one of two variations he has been studying in the salivas of female DBA/2J mice (personal communication). His DBA polymorphism is dominantly inherited, however, and further studies are necessary to determine whether the polymorphisms are related. |
